Follmann, Heveline D. M.
Naves, Alliny F.
Araujo, Rafael A.
Oliveira, Jr., Osvaldo N.
Total Authors: 8
 Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13566590 Sao Carlos, SP - Brazil
 Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 - USA
 Univ Sao Paulo, Inst Chem, CP 26077, BR-05513970 Sao Paulo - Brazil
 State Univ Maringa UEM, Dept Chem, Av Colombo 5790, BR-8702090 Maringa, Parana - Brazil
 Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 - USA
Total Affiliations: 5
CURRENT PHARMACEUTICAL DESIGN;
Web of Science Citations:
This review article provides an overview of hybrid and nanocomposite materials used as biomaterials in nanomedicine, focusing on applications in controlled drug delivery, tissue engineering, biosensors and theranostic systems. Special emphasis is placed on the importance of tuning the properties of nanocomposites, which can be achieved by choosing appropriate synthetic methods and seeking synergy among different types of materials, particularly exploiting their nanoscale nature. The challenges in fabrication for the nanocomposites are highlighted by classifying them as those comprising solely inorganic phases (inorganic/inorganic hybrids), organic phases (organic/organic hybrids) and both types of phases (organic/inorganic hybrids). A variety of examples are given for applications from the recent literature, from which one may infer that significant developments for effective use of hybrid materials require a delicate balance among structure, biocompatibility, and stability. (AU)