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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High risk of heterosexual transmission of human T-cell lymphotropic virus type 1 infection in Brazil

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Paiva, Arthur ; Smid, Jerusa ; Haziot, Michel E. J. ; Assone, Tatiane ; Pinheiro, Samara ; Fonseca, Luiz A. M. ; Penalva de Oliveira, Augusto C. ; Casseb, Jorge
Total Authors: 8
Document type: Journal article
Source: Journal of Medical Virology; v. 89, n. 7, p. 1287-1294, JUL 2017.
Web of Science Citations: 7

Human T-cell lymphotropic virus type 1 is transmitted primarily either through sexual intercourse or from mother to child. The current study investigated sexual transmission and compared the HTLV-1 proviral load between seroconcordant and serodiscordant couples by examining both men and women among the index partners without using subjective criteria to establish the direction of sexual transmission. Between January 2013 and May 2015, 178 HTLV-1-positive patients had spouses, 107 of which had tested partners, thus increasing the initial sample size (46 men and 61 women). Individuals co-infected with HTLV-2 or human immunodeficiency virus were not included in the analysis. From among the included participants, 26 men and 26 women were paired with each other, resulting in 26 seroconcordant couples; 12 seroconcordant couples were formed from another four men and eight women. Forty-three serodiscordant couples were formed from 16 men and 27 women. The rate of seroconcordance was 46.9%. The HTLV-1 proviral load was compared between 19 and 37 seroconcordant and serodiscondant couples, respectively, and the concordant couples showed higher proviral loads (P = 0.03). There were no differences between the groups according to age, relationship length, having a mother or sibling with HTLV-1, race, ethnicity, nationality, education, history of blood transfusion, HAM/TSP, ALT, or hepatitis C virus status. In multivariate analysis, relationship time was shown associated with ocurrence of seroconcordance status. The apparent association between high circulating levels of provirus and seroconcordance rate among couples suggests that proviral loads contribute markedly to the risk of sexual transmission, regardless of gender index. (AU)

FAPESP's process: 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants