Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

International high-risk clones of Klebsiella pneumoniae KPC-2/CC258 and Escherichia coli CTX-M-15/CC10 in urban lake waters

Full text
Nascimento, Tatiane ; Cantamessa, Rodrigo ; Melo, Luana ; Fernandes, Miriam R. ; Fraga, Edmir ; Dropa, Milena ; Sato, Maria I. Z. ; Cerdeira, Louise ; Lincopan, Nilton
Total Authors: 9
Document type: Journal article
Source: Science of The Total Environment; v. 598, p. 910-915, NOV 15 2017.
Web of Science Citations: 15

The emergence of high-risk clones of multidrug-resistant (MDR) bacteria in aquatic environments has generated an important public health problem, creating an urgent need to strengthen surveillance. This study reports the occurrence of clinically significant MDR Enterobacteriaceae and non-fermentative bacteria carrying carbapenemases (KPC-2), extended-spectrum beta-lactamases (CTX-M) and plasmid-mediated quinolone resistance (PMQR) genes in urban lakes and reservoirs, in Southeastern Brazil. In this regard, the detection of hospital-associated lineages of KPC-2-producing Klebsiella pneumoniae belonging to the international clonal complex CC258 (STH) and CTX-M-15-producing Escherichia coli belonging to the international CC10 (ST617), in an urban lake, is reported for the first time. Whole genome sequencing (WGS) analysis of KPC-2-producing K. pneumoniae ST11 revealed that bla(KPC-2) gene was carried by an IncN plasmid on a Tn4401b element. This study support that aquatic environments with public access can act as reservoirs of clinically important MDR bacteria, constituting a potential risk to human and animal health. On the other hand, the detection of high-risk clones highlights the extra-hospital spread of clinically significant bacteria into urban aquatic environments. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/23588-0 - Prevalence and diversity of multidrug-resistant Gram-negative bacteria in public aquatic environment and drinking water sources in São Paulo State: clinical and environmental impact
Grantee:Tatiane Nascimento
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/08593-9 - Pan-Resistome of beta-lactamase (KPC-2, CTX-M-8, CTX-M-15)-producing Klebsiella pneumoniae and Escherichia coli isolates endemic in Brazil
Grantee:Nilton Erbet Lincopan Huenuman
Support Opportunities: Regular Research Grants
FAPESP's process: 13/04725-0 - Monitoring of multidrug-resistant Gram-negative bacteria of medical importance (human & veterinary): clinical/environmental impact and development of therapeutic alternatives and technology innovation products
Grantee:Nilton Erbet Lincopan Huenuman
Support Opportunities: Regular Research Grants