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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unconventional Secretion of Heat Shock Proteins in Cancer

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Santos, Tiago Goss ; Martins, Vilma Regina ; Maroso Hajj, Glaucia Noeli
Total Authors: 3
Document type: Review article
Web of Science Citations: 18

Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu. HSPs do not possess secretion signal peptides, and their secretion was subject to widespread skepticism until the demonstration of the role of unconventional secretion forms such as exosomes. Secretion of HSPs may confer immune system modulation and be a cell-to-cell mediated form of increasing stress resistance. Thus, there is a wide potential for secreted HSPs in resistance of cancer therapy and in the development new therapeutic strategies. (AU)

FAPESP's process: 14/15550-9 - Translational control in cancer
Grantee:Glaucia Noeli Maroso Hajj
Support Opportunities: Regular Research Grants
FAPESP's process: 15/02098-3 - The role of stress inducible protein 1 (STI1) in the early embryonic vascular development and tumor angiogenesis
Grantee:Tiago Góss dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 09/14027-2 - Mechanisms associated with the function of prion protein and its ligand STI1/Hop: therapeutic approaches
Grantee:Vilma Regina Martins
Support Opportunities: Research Projects - Thematic Grants