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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Palladium(II)/N,N-disubstituted-N `-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

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Plutin, Ana M. ; Alvarez, Anislay ; Mocelo, Raul ; Ramos, Raul ; Castellano, Eduardo E. ; da Silva, Monize M. ; Villarreal, Wilmer ; Pavan, Fernando R. ; Meira, Cassio Santana ; Rodrigues Filho, Jose Simao ; Moreira, Diogo Rodrigo M. ; Soares, Milena Botelho P. ; Batista, Alzir A.
Total Authors: 13
Document type: Journal article
Source: Polyhedron; v. 132, p. 70-77, AUG 16 2017.
Web of Science Citations: 6
Abstract

The new complexes of Pd(II) with N,N-disubstituted-N'-acylthioureas:{[}(1) {[}Pd(dppf)(N,N-dimethyl-N'benzoylthioureato-k(2)O,S)]PF6, (2) {[}Pd(dppf)(N,N-diethyl-N'-benzoylthioureato-k(2)O,S)]PF6, (3) {[}Pd(dppf) (N,N-dibuthyl-N'-benzoylthioureato-k(2)O,S)]PE6, (4) {[}Pd(dPPO(N,N-diphenyl-N'-benzoylthioureato-k(2)O, S)]PF6, (5) {[}Pd(dppf)(N,N-diethyl-N'-furoylthioureato-k(2)O,S)]PF6, (6) {[}Pd(dppf)(N,N-diphenyl-N'-furoylthioureato-k(2)O,S)]PF6, (7) {[}Pd(dppf)(N,N-dimethyl-N'-thiophenylthioureato-k(2)O,S)]PF6, and (8) {[}Pd(dppf) (N,N-diphenyl-N'-thiophenylthioureato-k(2)O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The. results demonstrated that the compounds described here can be considered as promising anti Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/13691-4 - The crystallography as tool in the help to elucidate the mechanism of action of potential metallodrugs
Grantee:Eduardo Ernesto Castellano
Support type: Regular Research Grants