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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microscopes and technologies for imaging cells and their protein networks: From nano to atomic scale resolution

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Belizario, Jose E. ; Sangiuliano, Beatriz A. ; Viana-Santos, Beatriz ; Perez-Sosa, Marcela ; Caldeira, Izabela
Total Authors: 5
Document type: Review article
Source: TECHNOLOGY; v. 5, n. 2, p. 61-73, JUN 2017.
Web of Science Citations: 0

Advances in the high resolution microscopes and digital imaging technologies have allowed us to visualize diffusible signaling cascades from the protein receptors in the cell membrane to the nucleus. As multi-omics biology evolves over time, building predictable DNA-RNA-protein expression, protein-protein interaction networks and thereby spatiotemporal dynamics of molecular events will help us to uncover differences on cell morphology and physiology between normal and disease states. Here we present an update on optical, fluorescence and electron transmitted microscopes and mass spectrometer imaging technologies and various ways we can apply them for biological discovery and diagnose of human diseases. (AU)

FAPESP's process: 12/02497-7 - Expression analysis of genes regulated by protein Dermicidina in malignant melanoma cells G-361 by DNA microarray
Grantee:Nancy Marcela Pérez Sosa
Support Opportunities: Scholarships in Brazil - Master