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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immune development in HIV-exposed uninfected children born to HIV-infected women

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Miyamoto, Maristela ; Gouvea, Aida F. T. B. ; Ono, Erika ; Succi, Regina Celia M. ; Pahwa, Savita ; de Moraes-Pinto, Maria Isabel
Total Authors: 6
Document type: Journal article
Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 59, 2017.
Web of Science Citations: 5

ABSTRACT Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected (HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years; for plasma sCD14, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, IFN-γ, TNF-α, G-CSF, GM-CSF and MCP-1, which increased from birth to 12 months and then decreased at 6-12 years; and for TREC/106 PBMC at birth in HEU and controls. By contrast, plasma MIP-1β levels were lower in HEU than in controls (p=0.009) at 12 months, and IL-4 levels were higher in HEU than controls (p=0.04) at 6-12 years. Immune activation was higher in HEU at 12 months and at 6-12 years than controls based on frequencies of CD38+HLA-DR+CD8+T cells (p=0.05) and of CD38+HLA-DR+CD4+T cells (p=0.006). Resting memory and activated mature B cells increased from birth to 6-12 years in both groups. The development of the immune system in vertically HEU individuals is comparable to the general population in most parameters, but subtle or transient differences exist. Their role in influencing clinical incidences in HEU is unknown. (AU)

FAPESP's process: 10/09701-3 - Persistence of immune activation in lymphocytes of HIV-exposed no infected newborns, children and adolescents
Grantee:Maria Isabel de Moraes Pinto
Support Opportunities: Regular Research Grants
FAPESP's process: 10/09738-4 - Persistence of immune activation in lymphocytes of HIV-exposed noninfected newborns, children and adolescents.
Grantee:Maristela Miyamoto de Nóbrega
Support Opportunities: Scholarships in Brazil - Post-Doctorate