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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypotensive acute effect of photobiomodulation therapy on hypertensive rats

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Author(s):
Oishi, J. C. ; De Moraes, T. F. ; Buzinari, T. C. ; Carnio, E. C. ; Parizotto, N. A. ; Rodrigues, G. J.
Total Authors: 6
Document type: Journal article
Source: Life Sciences; v. 178, p. 56-60, JUN 1 2017.
Web of Science Citations: 3
Abstract

The purpose of this study was to evaluate the acute effect of photobiomodulation therapy (PBM) on arterial pressure in hypertensive and normotensive rats with application in an abdominal region. Normotensive (2K) and hypertensive (2K-1C) wistar rats were treated with PBM. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP) and heart rate (HR) were measured before, during and after PBM application. The nitric oxide (NO) serum concentration was measured before and after PBM application. Vascular reactivity study was performed in isolated thoracic aortas. Aluminum gallium arsenide (GaAlAs) diode laser was used, at 660 nm wavelength and 100 mW optical output The PBM application induced a decrease of SAP in 2K-1C rats. In 2K rats, the PBM application had no effect on SAP, DAP and MAP. Moreover, the magnitude of hypotensive effect was higher in 2K-1C than in 2K rats. The PBM application induced a decrease of HR in 2K-1C and 2K, with higher effect in 2K-1C rats. In 2K-1C, the hypotensive effect induced by PBM was longer than that obtained in 2K rats. PBM application induced an elevation of NO concentration in serum from 2K-1C and 2K rats, with higher effect in 2K-1C In isolated aortic rings PBM effect is dependent of NO release, and is not dependent of nitric oxide synthase (NOS) activation. Our results indicate that the abdominal acute application of PBM at 660 nm is able to induce a long lasting hypotensive effect in hypertensive rats and vasodilation by a NO dependent mechanism. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/24477-8 - Utilization of ruthenium complex as pharmacological strategy to revert and/or prevent the endothelial dysfunction
Grantee:Gerson Jhonatan Rodrigues
Support Opportunities: Research Grants - Young Investigators Grants