Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer

Full text
Assao, Agnes ; Nonogaki, Suely ; Pereira Lauris, Jose Roberto ; Carvalho, Andre Lopes ; Lopes Pinto, Clovis Antonio ; Soares, Fernando Augusto ; Kowalski, Luiz Paulo ; Oliveira, Denise Tostes
Total Authors: 8
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 21, n. 5, p. 1647-1657, JUN 2017.
Web of Science Citations: 3

Podoplanin and ezrin connection through Rho-A phosphorylation have been suggested as part of the activation pathway, in the process of tumor invasion and cell movement in oral squamous cell carcinomas. The aim of this study was to evaluate the correlation among podoplanin, ezrin, and Rho-A immunoexpressions in 91 squamous cells carcinomas of the lower lip and their influence in patient's prognosis. The immunoexpressions of podoplanin, ezrin, and Rho-A were evaluated through a semi-quantitative score method, based on the capture of 10 microscopic fields at the front of tumor invasion. The association and correlation of these proteins with the clinicopathological features were verified by Fischer's exact test and Spearman's test. The prognostic values were analyzed by Kaplan-Meier method and log-rank test. A statistically significant association between strong cytoplasmic podoplanin expression and alcohol (p = 0.024), loco-regional recurrences (p = 0.028), and lymph node metastasis (pN+) (p = 0.010) was found. The membranous (p = 0.000 and r = 0.384) and cytoplasmic (p = 0.000 and r = 0.344) podoplanin expression was statistically correlated with ezrin expression. Also, membranous podoplanin was significantly correlated with Rho-A expression (p = 0.006 and r = 0.282). The expressions of podoplanin, ezrin, and Rho-A were not significant prognostic factors for patients with squamous cell carcinomas of the lower lip. Therefore, our results confirm a correlation among podoplanin, ezrin, and Rho-A expressions in squamous cell carcinoma of the lip suggesting a cooperative participation of these proteins in cell movement and invasion. Furthermore, strong cytoplasmic podoplanin expression could be helpful to identify patients with squamous cell carcinoma of the lip and lower risk of loco-regional recurrences. (AU)

FAPESP's process: 12/13411-6 - The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 13/16999-7 - Correlation of podoplanin, ezrin and Rho-A expression in oral squamous cell carcinoma
Grantee:Agnes Assao
Support Opportunities: Scholarships in Brazil - Master