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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry

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Quini, Caio C. ; Prospero, Andre G. ; Calabresi, Marcos F. F. ; Moretto, Gustavo M. ; Zufelato, Nicholas ; Krishnan, Sunil ; Pina, Diana R. ; Oliveira, Ricardo B. ; Baffa, Oswaldo ; Bakuzis, Andris F. ; Miranda, Jose R. A.
Total Authors: 11
Document type: Journal article
Source: Nanomedicine-Nanotechnology Biology and Medicine; v. 13, n. 4, p. 1519-1529, MAY 2017.
Web of Science Citations: 9

We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR). The ACB had viable temporal resolution and accuracy to differentiate temporal parameters of liver accumulation, caused by vasculature extravasation and macrophages action. The biodistribution experiment showed different uptake profiles for different doses and injection protocols. Comparisons with the ESR system indicated a correlation index of 0.993. We present the ACB system as an accessible and versatile tool to monitor magnetic nanoparticles, allowing in vivo and real-time evaluations of distribution and quantitative assessments of particle concentrations. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/07639-9 - Gastrointestinal motility: clinical investigations, physiopathology and biopharmaceutical
Grantee:Ricardo Brandt de Oliveira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/20842-6 - Evaluation of pancreatic cancer influence on liver and kidneys metabolic functions
Grantee:Caio César Quini
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/18696-6 - New ACB applications using magnetic nanoparticles
Grantee:Caio César Quini
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/14914-0 - AC Biosusceptometry to assess accumulation of cancer-targeted magnetic nanoparticles in tumors for diagnostic and therapy
Grantee:Caio César Quini
Support Opportunities: Scholarships in Brazil - Post-Doctoral