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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles

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Affonso de Oliveira, Jessica Fernanda ; Saito, Angela ; Bido, Ariadne Tuckmantel ; Kobarg, Joerg ; Stassen, Hubert Karl ; Cardoso, Mateus Borba
Total Authors: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, MAY 2 2017.
Web of Science Citations: 18

The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli. In addition, these structures were not cell-death inducers and different steps of the mitotic cell cycle (prophase, anaphase and metaphase) were clearly identified. The superior biological results were attributed to a proper and tailored synthesis strategy. (AU)

FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 11/15937-2 - Funcionalization of silver nanoparticles with beta-lactam antibiotics: an alternative to bacterial resistance
Grantee:Jessica Fernanda Affonso de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support Opportunities: Research Projects - Thematic Grants