Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Benefits of Bifidobacterium animalis subsp lactis Probiotic in Experimental Periodontitis

Full text
Show less -
Oliveira, Luiz F. F. ; Salvador, Sergio L. ; Silva, Pedro H. F. ; Furlaneto, Flavia A. C. ; Figueiredo, Luciene ; Casarin, Renato ; Ervolino, Edilson ; Palioto, Daniela B. ; Souza, Sergio L. S. ; Taba, Jr., Mario ; Novaes, Jr., Arthur B. ; Messora, Michel R.
Total Authors: 12
Document type: Journal article
Source: Journal of Periodontology; v. 88, n. 2, p. 197-208, FEB 2017.
Web of Science Citations: 9

Background: This study evaluates effects of topical administration of probiotic bacteria of the genus Bifidobacterium on experimental periodontitis (EP) in rats. Methods: Thirty-two rats were divided into groups C (control; without EP), EP (EP only), C-HN019 (control+probiotic), and EP-HN019 (EP+probiotic). On day 0 of the experiment, animals of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFMs). In groups C-HN019 and EP-HN019, 1 mL of suspensions containing Bifidobacterium animalis subsp. lactis (B. lactis) HN019 was topically administered in the subgingival region of MFMs on days 0, 3, and 7. In groups C and EP, topical administrations were performed using a sham suspension (without probiotic). All animals were euthanized at day 14. Gingival tissue, hemimandibles, and oral biofilm were collected. Data were statistically analyzed (P < 0.05). Results: Group EP presented greater bone porosity, trabecular separation, and connective tissue attachment loss (CTAL) as well as reduced bone volume than all other groups (P < 0.05). In group EP-HN019, there were greater proportions of Actinomyces and Streptococcus-like species and lower proportions of Veillonella parvula, Capnocytophaga sputigena, Eikenella corrodens, and Prevotella intermedia-like species than group EP. Group EP-HN019 presented greater expressions of osteoprotegerin and beta-defensins than group EP (P < 0.05). Group EP presented greater levels of interleukin-1 beta and receptor activator of nuclear factor-kappa B ligand than group EP-HN019 (P < 0.05). Conclusion: Topical use of B. lactis HN019 promotes a protective effect against alveolar bone loss and CTAL sattributable to EP in rats, modifying immunoinflammatory and microbiologic parameters. (AU)

FAPESP's process: 13/25022-7 - Effects of Bifidobacterium animalis subsp. lactis HN019 and Bdellovibrios bacteriovorus HD100 on the experimental periodontitis in rats: microbiological, immunological, histological and genetic features of the host response
Grantee:Michel Reis Messora
Support Opportunities: Regular Research Grants