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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of tyrosol on Candida albicans, Candida glabrata and Streptococcus mutans biofilms developed on different surfaces

Monteiro, Douglas Roberto ; Arias, Lais Salomao ; Fernandes, Renan Aparecido ; Straioto, Fabiana Gouveia ; Barbosa, Debora Barros ; Pessan, Juliano Pelim ; Botazzo Delbem, Alberto Carlos
Total Authors: 7
Document type: Journal article
Source: AMERICAN JOURNAL OF DENTISTRY; v. 30, n. 1, p. 35-39, FEB 2017.
Web of Science Citations: 2

Purpose: To assess the effect of tyrosol on the production of hydrolytic enzymes (by Candida biofilm cells) and acid (by Streptococcus mutans biofilms), as well as to quantify single and mixed biofilms of these species formed on acrylic resin (AR) and hydroxyapatite (HA). Methods: Candida and S. mutans biofilms were formed on AR and HA in the presence of tyrosol during 48 hours. Next, acid proteinase, phospholipase and hemolytic activities of Candida biofilm cells were determined, while acid production by S. mutans biofilms was assessed by pH determination. The effect of tyrosol on mature biofilms (96 hours) was evaluated through quantification of total biomass, metabolic activity, number of colony-forming units and composition of biofilms' extracellular matrix. Data were analyzed by one and two-way ANOVA, followed by Tukey's and Holm-Sidak's tests (alpha = 0.05). Results: Treatments with tyrosol were not able to significantly reduce hydrolytic enzymes and acid production by Candida and S. mutans. Tyrosol only significantly reduced the metabolic activity of single biofilms of Candida species. (AU)

FAPESP's process: 13/10285-2 - Effect of tyrosol on virulence factors of Candida albicans, Candida glabrata and Streptococcus mutans
Grantee:Alberto Carlos Botazzo Delbem
Support type: Regular Research Grants
FAPESP's process: 13/03273-8 - Effect of Tyrosol on virulence factors of Candida albicans, Candida glabrata and Streptococcus mutans
Grantee:Douglas Roberto Monteiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/05507-9 - Effect of Tyrosol on the lactic acid production and on the ability to form biofilms by Streptococcus mutans
Grantee:Laís Salomão Arias
Support type: Scholarships in Brazil - Master