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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ACTH modulation on corticosterone, melatonin, testosterone and innate immune response in the tree frog Hypsiboas faber

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Author(s):
Giorgi Barsotti, Adriana Maria ; de Assis, Vania Regina ; Monteiro Titon, Stefanny Christie ; Titon Junior, Braz ; da Silva Ferreira, Zulma Felisbina ; Gomes, Fernando Ribeiro
Total Authors: 6
Document type: Journal article
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 204, p. 177-184, FEB 2017.
Web of Science Citations: 6
Abstract

The modulation exerted by glucocorticoids in physiological responses to stressors is essential for maintaining short-term homeostasis. However, highly frequent and/or prolonged activation of the hypothalamic-pituitary-adrenal/interrenal axis may inhibit processes that are important to long-term fitness and health, including reproduction and immunocompetence. The present study evaluates the response to adrenocorticotropic hormone (ACTH) injection in the adult male tree frog, Hypsiboas faber, as indicated by levels of plasma corticosterone (CORT), plasma testosterone (T), ocular melatonin (MEL), hematocrit and immune functioning (total leukocyte count and bacterial killing ability against Escherichia coli). All levels were measured 1, 3 and 6 h after treatment. ACTH increased CORT levels whilst decreasing T and MEL levels at 1 h post-treatment. 6 h after ACTH injection, hematocrit and MEL levels increased. ACTH treatment did not significantly modulate the immune measures over the time-range sampled. The hormonal changes observed in response to ACTH treatment suggest that stressors could act as inhibitors of reproductive activity, as well as differentially modulating melatonin levels at different time-points. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/10560-8 - Plasma leves of corticosterone, testosterone and immunocompetence in Bufonids.
Grantee:Vania Regina de Assis
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/00900-1 - Comparative study of the relationships between immunocompetence and plasmatic levels of gonadal and inter-renal steroids in toads
Grantee:Fernando Ribeiro Gomes
Support Opportunities: Regular Research Grants