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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High and Low Salt Intake during Pregnancy: Impact on Cardiac and Renal Structure in Newborns

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Seravalli, Priscila ; de Oliveira, Ivone Braga ; Zago, Breno Calazans ; de Castro, Isac ; Veras, Mariana Matera ; Alves-Rodrigues, Edson Nogueira ; Heimann, Joel C.
Total Authors: 7
Document type: Journal article
Source: PLoS One; v. 11, n. 8 AUG 25 2016.
Web of Science Citations: 2

Introduction Previous studies from our laboratory demonstrated that dietary salt overload and salt restriction during pregnancy were associated with cardiac and renal structural and/or functional alterations in adult offspring. The present study evaluated renal and cardiac structure and the local renin-angiotensin system in newborns from dams fed high-, normal-or low-salt diets during pregnancy. Methods Female Wistar rats were fed low-(LS, 0.15% NaCl), normal-(NS, 1.3% NaCl) or high-(HS, 8% NaCl) salt diets during pregnancy. Kidneys and hearts were collected from newborns (n = 6-8/group) during the first 24 hours after birth to evaluate possible changes in structure using stereology. Protein expression of renin-angiotensin system components was evaluated using an indirect enzyme-linked immunosorbent assay (ELISA). Results No differences between groups were observed in total renal volume, volume of renal compartments or number of glomeruli. The transverse diameter of the nuclei of cardiomyocytes was greater in HS than NS males in the left and right ventricles. Protein expression of the AT1 receptor was lower in the kidneys of the LS than in those of the NS and HS males but not females. Protein expression of the AT2 receptor was lower in the kidneys of the LS males and females than in those of the NS males and females. Conclusion High salt intake during pregnancy induced left and right ventricular hypertrophy in male newborns. Salt restriction during pregnancy reduced the expression of renal angiotensin II receptors in newborns. (AU)

FAPESP's process: 13/00458-7 - Sodium chloride overload or restriction during pregnancy: cardiac and renal structural alterations in the neonate
Grantee:Joel Claudio Heimann
Support Opportunities: Regular Research Grants