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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Absence of significant adverse events following thalidomide administration in bitches diagnosed with mammary gland carcinomas

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de Campos, C. B. ; Lavalle, G. E. ; Ligorio, S. Fialho ; Nunes, F. Camargo ; Carneiro, R. A. ; Amorim, R. L. ; Cassali, G. D.
Total Authors: 7
Document type: Journal article
Source: VETERINARY RECORD; v. 179, n. 20, p. 514-U63, NOV 2016.
Web of Science Citations: 4

The aim of the study was to evaluate the incidence of adverse events (AEs) in female dogs diagnosed with advanced clinical stage mammary gland neoplasms following treatment with thalidomide. A prospective analysis of 29 female dogs treated with a high dose (HD) of 20 mg/kg/day of thalidomide for three months followed by a low dose (LD) of 10 mg/kg/day of thalidomide for three months was performed. All patients underwent physical examination, complete blood count, serum biochemistry profile, thoracic radiographs, and abdominal ultrasound analysis before the treatment and after the HD and LD. Clinical AEs were absent in 16/29 (55.17 per cent) patients following HD. An initial 3-5 day period of somnolence was described in 4/29 (13.79 per cent), prolonged somnolence in 5/29 (17.24 per cent), a short period of somnolence lasting only a few hours in 3/29 (10.34 per cent), and difficulty to rouse was described in 5/29 (17.24 per cent) cases. Two patients (6.89 per cent) presented with prolonged somnolence that interfered with activities of daily living, resulting in anticipation of the dose reduction to the proposed LD after 15 days of the HD treatment. Following dose reduction, AE improvement was observed in all patients. Albeit remaining within the reference ranges, erythrocytes, haematocrit, total leucocyte count, neutrophils, lymphocytes, monocytes and gamma-glutamyltranspeptidase showed significant alteration associated to thalidomide treatment. (AU)

FAPESP's process: 14/01329-9 - Evaluation of Thalidomide in the Treatment of Canine Malignant Mammary Gland Neoplasms
Grantee:Cecília Bonolo de Campos
Support type: Scholarships in Brazil - Doctorate