Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity

Full text
Motta, Erick V. S. ; Lemos, Marivane ; Costa, Juliana C. ; Bandero-Filho, Vilmar C. ; Sasse, Astrid ; Sheridan, Helen ; Bastos, Jairo K.
Total Authors: 7
Document type: Journal article
Source: Chemico-Biological Interactions; v. 261, p. 145-155, JAN 5 2017.
Web of Science Citations: 9

Nine new methylated galloylquinic acids were isolated from an aqueous fraction of Copaifera langsdorffii (Fabaceae-Caesalpinioideae) leaf hydroalcoholic extract (3-8, 11, 12, and 14), along with three known methylated galloylquinic acids (1, 2, and 15) and four galloylquinic acids (9, 10, 13, and 16). These compounds were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. They were further tested in a gastroprotection assay (Ethanol-HCl induced ulcer model in mice), in which all of them significantly reduced the total lesion area, and increased the cure ratio in comparison with pantoprazole. Also, the tested compounds displayed cytotoxicity against gastric adenocarcinoma cells. (C) 2016 Published by Elsevier Ireland Ltd. (AU)

FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/09727-8 - Toxicological and pharmacological in vitro and in vivo prospection of oil resins, leaf extracts and isolated compounds from Copaifera oblongifolia Mart. ex Hayne and C. duckei Dwyer
Grantee:Marivane Lemos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/01336-0 - Development of analytical method by high performance liquid chromatography for quantification of galloylquinic compounds isolated from Copaifera langsdorffii Desf. leaves and its application in seasonal analysis.
Grantee:Erick Vicente da Silva Motta
Support Opportunities: Scholarships in Brazil - Master