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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

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Hupalo, Daniel N. ; Luo, Zunping ; Melnikov, Alexandre ; Sutton, Patrick L. ; Rogov, Peter ; Escalante, Ananias ; Vallejo, Andres F. ; Herrera, Socrates ; Arevalo-Herrera, Myriam ; Fan, Qi ; Wang, Ying ; Cui, Liwang ; Lucas, Carmen M. ; Durand, Salomon ; Sanchez, Juan F. ; Baldeviano, G. Christian ; Lescano, Andres G. ; Laman, Moses ; Barnadas, Celine ; Barry, Alyssa ; Mueller, Ivo ; Kazura, James W. ; Eapen, Alex ; Kanagaraj, Deena ; Valecha, Neena ; Ferreira, Marcelo U. ; Roobsoong, Wanlapa ; Nguitragool, Wang ; Sattabonkot, Jetsumon ; Gamboa, Dionicia ; Kosek, Margaret ; Vinetz, Joseph M. ; Gonzalez-Ceron, Lilia ; Birren, Bruce W. ; Neafsey, Daniel E. ; Carlton, Jane M.
Total Authors: 36
Document type: Journal article
Source: Nature Genetics; v. 48, n. 8, p. 953+, AUG 2016.
Web of Science Citations: 48
Abstract

Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally. (AU)

FAPESP's process: 09/52729-9 - Determinants and consequences of asymptomatic carriage of malaria parasites: population-based studies in rural Brazilian Amazonia
Grantee:Marcelo Urbano Ferreira
Support Opportunities: Regular Research Grants