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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia

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Author(s):
Soares, Renan Rocha ; Maesta, Izildinha ; Colon, Jose ; Braga, Antonio ; Salazar, Aleydah ; Charry, Rafael Cortes ; Sun, Sue Yazaki ; Goldstein, Donald P. ; Berkowitz, Ross S.
Total Authors: 9
Document type: Journal article
Source: GYNECOLOGIC ONCOLOGY; v. 142, n. 3, p. 496-500, SEP 2016.
Web of Science Citations: 4
Abstract

Objectives. To compare complete hydatidiform mole (CHM) clinical presentation and risk factors associated with GTN development between North American and South American adolescents. Methods. This non-concurrent cohort study was undertaken including adolescents with CHM referred to centers in North America (New England Trophoblastic Disease Center, Harvard University, USA), and South America (Botucatu Trophoblastic Disease Center-Sao Paulo State University, Brazil; Trophoblastic Unit of Central University of Venezuela and Matemidad Concepcion Palacios of Caracas, Venezuela) between 1990 and 2012. Data were obtained from medical records and pathology reports. Study participants were allocated into 2 groups: North America (NA) and South America (SA). Results. In NA and SA, 13.1% and 30.9% of patients with hydatidiform mole were adolescents, respectively. Of these, 77.6% in NA and 86.1% in SA had pathologic diagnosis of CHM (p = 0.121). Vaginal bleeding (SA = 69% vs NA = 51%; p = 0.020), anemia (SA = 48% vs NA = 18%; p<0.001), and elevated serum hCG (SA = 232,860 mIU/mL vs NA = 136,412 mIU/mL; p = 0.039) were more frequent in SA than in NA. Median gestational age at diagnosis (SA = 12 weeks, NA = 11 weeks; p = 0.030) differed whereas GTN development rate (SA = 20%, NA = 27%; p = 0.282) showed no significant difference between groups. Compared to NA, medical complications and clinical factors associated with post-molar GTN were more frequent among SA adolescents. Conclusions. Medical complications and clinical factors associated with GTN development were more frequent in SA than in NA adolescents with CHM, suggesting that, in South America, awareness about the importance of diagnosing molar pregnancy early and considering CHM in the differential diagnosis in adolescents suspected to be pregnant should be raised. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/09633-6 - Natural history of molar pregnancy in adolescents: a study in North and South America
Grantee:Izildinha Maestá
Support Opportunities: Scholarships abroad - Research