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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

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Author(s):
Moreno, Fernando Salvador ; Heidor, Renato ; Pogribny, Igor P.
Total Authors: 3
Document type: Review article
Source: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 68, n. 5, p. 719-733, 2016.
Web of Science Citations: 8
Abstract

Hepatocellular carcinoma (HCC) is an aggressive and life-threatening disease often diagnosed at intermediate or advanced stages, which substantially limits therapeutic approaches to its successful treatment. This indicates that the prevention of HCC may be the most promising strategy in reducing its incidence and mortality. Emerging evidence indicates that numerous nutrients and nonnutrient dietary bioactive components can reduce the occurrence and/or delay the development of HCC through modifications of deregulated epigenetic mechanisms. This review examines the existing knowledge on the epigenetic mechanism-based studies in in vitro and in vivo models of HCC on the chemopreventive potential of epigenetic food components, including dietary methyl-group donors, epigallocatechin-3-gallate, sodium butyrate, resveratrol, curcumin, and sulforaphane, on liver carcinogenesis. Future direction and potential challenges in the effective use of bioactive food constituents in the prevention of HCC are highlighted and discussed. (AU)

FAPESP's process: 13/20477-6 - Evaluation of the anti-neoplastic activity of tributyrin alone or in combination with sorafenib in Fischer 344 and Nude rowett rats
Grantee:Fernando Salvador Moreno
Support type: Regular Research Grants