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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?

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Author(s):
Hora, A. S. [1, 2] ; Tonietti, P. O. [3] ; Taniwaki, S. A. [2] ; Asano, K. M. [1, 2] ; Maiorka, P. [3] ; Richtzenhain, L. J. [1, 2] ; Brandao, P. E. [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Prevent Vet Med & Anim Hlth, Sch Vet Med, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Coronavirus Res Grp, Sch Vet Med, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Pathol, Sch Vet Med, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BIOMED RESEARCH INTERNATIONAL; 2016.
Web of Science Citations: 1
Abstract

Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a-c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account. (AU)

FAPESP's process: 10/07492-8 - Feline coronavirus: occurrence, viral load and genetic diversity in cats from catteries from São Paulo and Rio de Janeiro, Brazil
Grantee:Paulo Eduardo Brandão
Support Opportunities: Regular Research Grants
FAPESP's process: 09/17535-9 - Feline coronavirus: occurence, vira load ando genetic diversity in cats from catteries from São Paulo and Rio de Janeiro, Brazil
Grantee:Aline Santana da Hora
Support Opportunities: Scholarships in Brazil - Doctorate