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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High-intensity resistance training attenuates dexamethasone-induced muscle atrophy

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Author(s):
Krug, Andre L. O. [1] ; Macedo, Anderson G. [1] ; Zago, Anderson S. [2] ; Rush, James W. E. [3] ; Santos, Carlos F. [4] ; Amaral, Sandra L. [1, 2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, Univ Fed Sao Carlos, PIPGCF UFscar UNESP, Joint Grad Program Physiol Sci, Sao Paulo - Brazil
[2] Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Ave Eng Luiz Edmundo Carrijo Coube, Sao Paulo - Brazil
[3] Univ Waterloo, Dept Kinesiol, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1 - Canada
[4] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: MUSCLE & NERVE; v. 53, n. 5, p. 779-788, MAY 2016.
Web of Science Citations: 6
Abstract

IntroductionIn this study we investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. Methods: Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5mg/kg/day, intraperitoneally) or saline. Results: DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy through a combination of low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for control and DEX, respectively) protein levels. Conclusion: RT attenuated DEX-induced muscle atrophy through a combination of increases in mTOR and p70S6K protein levels and a low increase in MuRF-1 protein level. Muscle Nerve53: 779-788, 2016 (AU)

FAPESP's process: 12/21820-3 - The role of resistance exercise on muscle atrophy induced by Dexamethasone
Grantee:André Luis de Oliveira Krug
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/21522-0 - Role of renin-antiotensin-system and simpathetic nervous system in dexamethasone-induced hypertension: preventive effects of exercise training
Grantee:Sandra Lia do Amaral Cardoso
Support Opportunities: Regular Research Grants