Correia, Jose Tiago M.
Acconcia, Lais V.
Total Authors: 3
 Univ Estadual Campinas, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY;
Web of Science Citations:
In this article, we describe the development of a convergent organocatalytic strategy to prepare the indolizidinic core of the pumiliotoxin A alkaloid family. The key step of the proposed strategy is based on a diastereoselective N-heterocyclic carbene catalyzed benzoin reaction, in which the Breslow intermediate generated from an enal moiety (umpolung a(1) to d(1) - acyl anion equivalent) attacks a ketone moiety intramolecularly to provide the indolizidinone core in good yield with good selectivity. (AU)