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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF AMLODIPINE BESYLATE AND HYDROCHLOROTHIAZIDE IN SYNTHETIC URINE SAMPLES USING A BORON-DOPED DIAMOND ELECTRODE

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Author(s):
Laís Pereira Silva [1] ; Bruna C. Lourencao [2] ; Orlando Fatibello-Filho [3]
Total Authors: 3
Affiliation:
[1] Universidade Federal de São Carlos. Departamento de Química - Brasil
[2] Universidade Federal de São Carlos. Departamento de Química - Brasil
[3] Universidade Federal de São Carlos. Departamento de Química - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Química Nova; v. 38, n. 6, p. 801-806, 2015-07-00.
Abstract

<p>A novel method for simultaneous voltammetric determination of the antihypertensive drugs, amlodipine besylate (AML) and hydrochlorothiazide (HTZ) in synthetic urine samples was developed. Determination was carried out with a cathodically pretreated boron-doped diamond electrode (CPT-BDD) using square-wave voltammetry (SWV) and Britton-Robinson buffer solution at pH 2 as the supporting electrolyte. AML and HTZ exhibited oxidation peaks at 0.88 V and 1.30 V, respectively. The difference in potentials of 0.42 V allowed the simultaneous determination of these two analytes. The analytical curve showed linear response in the concentration range from 0.200 to 9.09 µmol L<sup>-1</sup> for AML and from 4.00 to 100 µmol L<sup>-1</sup> for HTZ, with a limit of detection (LOD) of 60.0 nmol L<sup>-1</sup> and of 2.00 µmol L<sup>-1</sup> for AML and HTZ, respectively. Recoveries of these analytes ranged from 91.0 to 107%. The proposed method using SWV and a CPT-BDD electrode is simple, fast and low cost, representing a good alternative for simultaneous determination of AML and HTZ in urine samples.</p> (AU)

FAPESP's process: 14/03019-7 - Evaluation and analytical application of boron doped diamond porous electrodes for voltammetric determination of biomolecules, ascorbic acid, uric acid, dopamine and adrenaline in biological fluids and/or pharmaceutical formulations
Grantee:Bruna Cláudia Lourenção
Support Opportunities: Scholarships in Brazil - Post-Doctoral