Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cervicovaginal bacterial count and failure of metronidazole therapy for bacterial vaginosis

Full text
Author(s):
Luchiari, Heloise R. [1] ; Ferreira, Carolina S. T. [1] ; Golim, Marjorie A. [2] ; Silva, Marcia G. [1] ; Marconi, Camila [3]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Botucatu, SP - Brazil
[2] UNESP Univ Estadual Paulista, Botucatu Med Sch, Ctr Blood, Botucatu, SP - Brazil
[3] UFPR Univ Fed Parana, Setor Ciencias Biol, Dept Basic Pathol, BR-81531980 Curitiba, Parana - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Gynecology & Obstetrics; v. 132, n. 3, p. 297-301, MAR 2016.
Web of Science Citations: 1
Abstract

Objective: To evaluate whether total bacterial count in cervicovaginal fluid is associated with failure of metronidazole therapy for bacterial vaginosis. Methods: In a cross-sectional study, women attending a primary health center in Botucatu, Sao Paulo, Brazil, for routine cervical screening between September 2012 and October 2013 were enrolled. Women who tested positive for bacterial vaginosis (Nugent classification) were offered oral metronidazole. Women who completed metronidazole treatment and an equal number of control women with normal vaginal flora at initial screening were included in analyses of total bacterial count, assessed by flow cytometry of cervicovaginal fluid samples. Results: Of 287 women who enrolled, 49 were excluded because they tested positive for trichomoniasis, chlamydial endocervicitis, gonorrhea, or candidiasis. Among the remaining 238, 85 (35.7%) had bacterial vaginosis. Among 36 women evaluated at follow-up, 23 (63.9%) had successfully restored lactobacilli-dominant flora, 12 (33.3%) had persistent bacterial vaginosis, and 1 (2.8%) had vaginal candidiasis (excluded from flow cytometry). Total bacterial count did not differ between 35 women with bacterial vaginosis and 35 with normal vaginal flora (P = 0.62). Total bacterial count did not differ at enrollment between women who went onto have persistent bacterial vaginosis and those who had successful treatment (P = 0.78). Conclusion: Failure of oral metronidazole therapy for bacterial vaginosis was not associated with total bacterial count in cervicovaginal fluid. (C) 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 12/16800-3 - Characterization of the vaginal microbiome of Brazilian women in reproductive age
Grantee:Márcia Guimarães da Silva
Support type: Regular Research Grants
FAPESP's process: 12/10403-2 - Characterization of the vaginal microbiome of Brazilian women of reproductive age
Grantee:Camila Marconi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/01750-3 - Assessment of the relation between flow cytometry bacterial count and outcome of bacterial vaginosis treatment
Grantee:Heloise Ranucci Luchiari
Support type: Scholarships in Brazil - Scientific Initiation