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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections

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Assone, Tatiane [1, 2] ; Paiva, Arthur [2] ; Fonseca, Luiz Augusto M. [3] ; Casseb, Jorge [1, 2]
Total Authors: 4
[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immune Deficiencies, LIM56, Av Dr Eneas de Carvalho Aguiar 500, 3rd Floo, Sao Paulo, SP - Brazil
[2] Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: Viruses-Basel; v. 8, n. 2 FEB 2016.
Web of Science Citations: 7

Human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) are prevalent worldwide, and share similar means of transmission. These infections may influence each other in evolution and outcome, including cancer or immunodeficiency. Many studies have reported the influence of genetic markers on the host immune response against different persistent viral infections, such as HTLV-1 infection, pointing to the importance of the individual genetic background on their outcomes. However, despite recent advances on the knowledge of the pathogenesis of HTLV-1 infection, gaps in the understanding of the role of the individual genetic background on the progress to disease clinically manifested still remain. In this scenario, much less is known regarding the influence of genetic factors in the context of dual or triple infections or their influence on the underlying mechanisms that lead to outcomes that differ from those observed in monoinfection. This review describes the main factors involved in the virus-host balance, especially for some particular human leukocyte antigen (HLA) haplotypes, and other important genetic markers in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other persistent viruses, such as HIV and HCV. (AU)

FAPESP's process: 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants
FAPESP's process: 14/22827-7 - Prevalence and incidence of early central nervous system disturbance in HTLV-1-infected subjects in Brazil
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants