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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cognition and impulsivity in adults with attention deficit hyperactivity disorder with and without cocaine and/or crack dependence

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Miguel, Carmen S. [1] ; Martins, Paula A. [2] ; Moleda, Nathalya [3] ; Klein, Margarete [1] ; Chaim-Avancini, Tiffany [4] ; Gobbo, Maria A. [1] ; Alves, Tania M. [1] ; Silva, Maria A. [1] ; Louza, Mario R. [1, 2]
Total Authors: 9
[1] Univ Sao Paulo, Res Program Attent Deficit Hyperact Disorder Adul, Dept Psychiat, Sch Med, Rua Dr Ovidio Pires de Campos, 785-3 Andar, BR-05403010 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Psychiat, Sch Med, Program Early Evaluat & Treatment Psychosis, Rua Dr Ovidio Pires de Campos, 785-3 Andar, BR-05403010 Sao Paulo, SP - Brazil
[3] Univ Prebiteriana Mackenzie, Rua Consolacao 930, BR-01302907 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Psychiat, LIM21, Lab Med Res 21, Specializing Neuroimaging, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DRUG AND ALCOHOL DEPENDENCE; v. 160, p. 97-104, MAR 2016.
Web of Science Citations: 8

Background: Substance use disorder (SUD) is a common comorbidity in adults with attention deficit hyperactivity disorder (ADHD). However,there have been few studies on cognitive profiles of these patients. Impulsivity is also commonly increased in both disorders. The central aim of this study was to compare cognition and impulsivity in subjects who had ADHD and cocaine dependence (ADHD + COC group) to those with ADHD only (ADHD-noSUD group). We hypothesized that the ADHD + COC group would show more marked cognitive dysfunction and greater impulsivity than their counterparts with ADHD only. Methods: A total of 70 adult patients diagnosed with ADHD according to (DSM-IV-TR) criteria were enrolled; 36 with ADHD + COC and 34 with ADHD-noSUD. All study participants were evaluated with a sociodemographic questionnaire; the Mini International Neuropsychiatric Interview; the Adult ADHD Self-Report Scale; the Addiction Severity Index; the Alcohol, Smoking and Substance Involvement Screening Test; the Barratt Impulsiveness Scale; and a comprehensive neurocognitive battery. Results: Compared to individuals with ADHD-noSUD, ADHD + COC individuals had significantly lower mean IQ and higher motor impulsivity. On average, the ADHD + COC group also performed more poorly on tasks assessing verbal skills, vigilance, implicit learning during decision making, and ADHD-noSUD performed more poorly on selective attention, information processing, and visual search. Conclusions: Our results support the integrative theory of ADHD based on the cognitive and affective neuroscience model, and suggests that ADHD-noSUD patients have impairments in cognitive regulation, while ADHD + COC patients have impairments in both cognitive and affective regulation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/15106-3 - Comparative study of the cognitive performance in adults with attention-deficit hyperactivity disorder (ADHD) with substance use disorder (SUD) and a group of adults with ADHD without SUD
Grantee:Mario Rodrigues Louzã Neto
Support Opportunities: Regular Research Grants