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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-kappa B Factor as Prognostic Markers in Mammary Tumors

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Author(s):
Martins, Gustavo Rodrigues [1] ; Gelaleti, Gabriela Bottaro [2] ; Moschetta, Marina Gobbe [1] ; Maschio-Signorini, Larissa Bazela [2] ; Pires de Campos Zuccari, Debora Ap [3]
Total Authors: 5
Affiliation:
[1] Grad Program Hlth Sci, Dept Mol Biol, LIMC, Fac Med Sao Jose Rio Do Preto FAMERP, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista Julio Mesquita Filho UNESP, Grad Program Genet, LIMC, Fac Med Sao Jose Rio Do Preto FAMERP, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Fac Med Sao Jose Rio Do Preto FAMERP, LIMC, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Mediators of Inflammation; 2016.
Web of Science Citations: 9
Abstract

Inflammation results in the production of cytokines, such as interleukin-(IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-alpha with procarcinogenic activity. Furthermore, NF-kappa B is the major link between inflammation and tumorigenesis. This study verified the interaction between active inflammatory cytokines in the tumor microenvironment and serum of female dogs with mammary tumors and their correlation with the clinicopathological characteristics and overall survival. Measurement of gene expression was performed by qPCR and protein levels by ELISA/Luminex. High gene and protein expression levels of NF-kappa B, IL-6, and TNF-alpha were found in association with characteristics that reflect worse prognosis and a negative correlation between TNF-alpha protein expression and survival time was observed (p. < 0.05). In contrast, high gene and protein expression levels of IL-4 and IL-10 were associated with characteristics of better prognosis and an increased level of IL-4 and a longer survival time of animals were obtained (p. < 0.05). In addition, there was a positive correlation between TNF-alpha and IL-6 expression in association with NF kappa B The results show a significant correlation of these cytokines with tumor development, associated with NF-kappa B expression and cytokines promodulation, showing that these biological factors could be used as predictive and prognosticmarkers in breast cancer. (AU)

FAPESP's process: 12/06098-0 - Modulation of interleukin 17b and 25 activity associated with melatonin as inductor of apoptosis in cell culture of mammary neoplasms
Grantee:Debora Aparecida Pires de Campos Zuccari
Support type: Regular Research Grants