The Prodrug Approach: A Successful Tool for Improv... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

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Author(s):
Jornada, Daniela Hartmann [1] ; dos Santos Fernandes, Guilherme Felipe [1] ; Chiba, Diego Eidy [1] ; Ferreira de Melo, Thais Regina [1] ; dos Santos, Jean Leandro [1] ; Chung, Man Chin [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Rodovia Araraquara Jau Km 01, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Molecules; v. 21, n. 1 JAN 2016.
Web of Science Citations: 29
Abstract

Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years. (AU)

FAPESP's process: 14/14980-0 - Drug design, synthesis and biological evaluation of hibrids with potential activity on the Alzheimer's Disease treatment
Grantee:Chung Man Chin
Support Opportunities: Regular Research Grants
FAPESP's process: 14/24811-0 - Design and synthesis of new 1,4-di-N-oxide quinoxaline as antitubercular compounds to treat multi drug-resistant (MDR) and latent tuberculosis
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 14/02240-1 - Design, Synthesis and anti Mycobacterium tuberculosis activity of new N-oxides derivatives
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/06755-6 - Synthesis and pharmacological evaluation of new pomalidomide derivatives to treat sickle cell disease symptoms
Grantee:Thaís Regina Ferreira de Melo
Support Opportunities: Scholarships in Brazil - Doctorate