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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N `-acyl thiourea complexes

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Author(s):
Plutin, Ana M. [1] ; Alvarez, Anislay [1] ; Mocelo, Raul [1] ; Ramos, Raul [1] ; Castellano, Eduardo E. [2] ; da Silva, Monize M. [3] ; Colina-Vegas, Legna [3] ; Pavan, Fernando R. [4] ; Batista, Alzir A. [3]
Total Authors: 9
Affiliation:
[1] Univ La Habana, Fac Quim, Havana - Cuba
[2] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
[4] UNESP, Fac Ciencias Farmaceut, Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Inorganic Chemistry Communications; v. 63, p. 74-80, JAN 2016.
Web of Science Citations: 14
Abstract

Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N'-acyl thiourea complexes with general formulae {[}Pt(dppf)(L)]PF6, {[}dppf = 1,1'-bis (diphenylphosphino)ferrocene; L = N,N-disubstituted-N'-acyl thioureas] is reported. The complexes were characterized by elemental analysis, molar conductivity, IR, NMR (H-1, C-13 and P-31[H-1]) spectroscopy. The spectroscopic data are consistent with the complexes containing one dppf and one O, S chelated ligand. The crystal structures of complexes with N,N-diphenyl-N'-benzoylthiourea (L4), N,N-diethyl-N'-furoylthiourea (L5) and N,N-diphenyl-N'-(thiophene-2-carbonyl)thiourea (L8) were determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar structures. The complexes were screened with respect to their anti-M. tuberculosis activity (H37Rv ATCC 27294). (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/14957-5 - Research potential against tuberculosis of a new class of furoxan compounds and nanostructured compounds of the ruthenium(II) and copper (II)
Grantee:Fernando Rogério Pavan
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/13691-4 - The crystallography as tool in the help to elucidate the mechanism of action of potential metallodrugs
Grantee:Eduardo Ernesto Castellano
Support type: Regular Research Grants