Innate immunity in tuberculosis: how the sensing o... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

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Author(s):
Amaral, Eduardo P. [1] ; Lasunskaia, Elena B. [2] ; D'Imperio-Lima, Maria Regina [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, Sao Paulo - Brazil
[2] State Univ North Fluminense, Lab Recognit Biol, Ctr Biosci & Biotechnol, Rio De Janeiro - Brazil
Total Affiliations: 2
Document type: Review article
Source: Microbes and Infection; v. 18, n. 1, p. 11-20, JAN 2016.
Web of Science Citations: 22
Abstract

The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the cell death pathways in infected macrophages and, consequently, the pathogenesis of tuberculosis. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. (AU)

FAPESP's process: 10/19246-1 - Role of inflammasome activation in development of the tuberculosis pathogeny induced by hypervirulent clinical isolates
Grantee:Eduardo Pinheiro Amaral
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07140-2 - Role of inflammasomas in the pathogenesis of tuberculosis caused by hypervirulent clinical isolates of mycobacteria
Grantee:Maria Regina D'Império Lima
Support Opportunities: Regular Research Grants