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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

alpha-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus

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Matias, A. C. [1] ; Biazolla, G. [1] ; Cerchiaro, G. [1] ; Keppler, A. F. [1]
Total Authors: 4
[1] Fed Univ ABC CCNH, UFABC, Ctr Nat Sci & Humanities, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry; v. 24, n. 2, p. 232-239, JAN 15 2016.
Web of Science Citations: 4

Nitrone-containing compounds are commonly employed as spin traps of free radical species in chemical and biological studies. Some molecules as alpha-phenyl-N-t-butyl nitrone (PBN) and its derivatives have been tested as potential drugs to treat oxidative stress related diseases, as Alzheimer and stroke for example. In this work we report the design and the synthesis of alpha-aryl-N-aryl nitrones and their cytoprotection profile on human neuroblastoma cells (SH-SY5Y) under induced oxidative stress. All the nine synthesized nitrones showed a significant response at low micromolar concentration. The selected compound 8 (alpha-phenyl-N-phenyl nitrone) increased the reduced glutathione (GSH) levels by 65% and lowered the necrotic cell death from 25.8% to 3.8%. Based on our data, the designed highly conjugated nitrone double-bond skeleton can be considered as a good scaffold for further studies regarding oxidative stress-related diseases. (c) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/15534-3 - Synthesis of nitrones with pharmacological potential
Grantee:Giovanna Biazolla
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/07717-5 - Nitrones and hydroxylamines with pharmacological properties: synthesis, exploration of antioxidant activity and cellular studies
Grantee:Artur Franz Keppler
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/01397-9 - Effects of metalloenzyme superoxide dismutase expression in the generation of reactive oxygen species in cultured mammalian cells and in motor neurons
Grantee:Giselle Cerchiaro
Support type: Regular Research Grants