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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Novel binuclear mu-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential

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Seuanes, Gabriela Campos [1] ; Moreira, Mariete Barbosa [1] ; Petta, Tania [1] ; Freire de Moraes Del Lama, Maria Perpetua [2, 3] ; Beraldo de Moraes, Luiz Alberto [1] ; Moraes de Oliveira, Anderson Rodrigo [1] ; Zumstein Georgetto Naal, Rose Mary [3, 2] ; Nikolaou, Sofia [1]
Total Authors: 8
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto - Brazil
[2] Inst Nacl Ciencia & Tecnol Bioanalit, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, BR-14040903 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Inorganic Biochemistry; v. 153, p. 178-185, DEC 2015.
Web of Science Citations: 4

This work presents the synthesis and characterization of two novel binuclear ruthenium compounds of general formula {[}Ru2O(carb)(2)(PY)(6)](PF6)(2), where py = pyridine and carb are the non-steroidal anti-inflammatory drugs ibuprofen (1) and ketoprofen (2). Both complexes were characterized by ESI-MS/MS spectrometry. The fragmentation patterns, which confirm the proposed structures, are presented. Besides that compounds 1 and 2 present the charge transfer transitions within 325-330 nm; and the intra-core transitions around 585 nm, which is the typical spectra profile for {[}Ru2O] analogues. This suggests the carboxylate bridge has little influence in their electronic structure. The effects of the diruthenium complexes on Ig-E mediated mast cell activation were evaluated by measuring the enzyme beta-hexosaminidase released by mast cells stimulated by antigen. The inhibitory potential of the ketoprofen complex against mast cell stimulation suggests its promising application as a therapeutic agent for treating or preventing IgE-mediated allergic diseases. In addition, in vitro metabolism assays had shown that the ibuprofen complex is metabolized by the cytochrome P450 enzymes. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/23245-6 - Nitric oxide releasers based on ruthenium carboxylates and their interaction with some relevant biomolecules
Grantee:Sofia Nikolaou
Support Opportunities: Regular Research Grants