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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study

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Kim, Lenise Jihe [1] ; Coelho, Fernando Morgadinho [1, 2] ; Hirotsu, Camila [1] ; Araujo, Paula [1] ; Bittencourt, Lia [1] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Neurol & Neurocirurgia, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 11, n. 12, p. 1377-1384, 2015.
Web of Science Citations: 4

Objectives: Narcolepsy is a disabling disease with a delayed diagnosis. At least 3 years before the disorder identification, several comorbidities can be observed in patients with narcolepsy. The early recognition of narcolepsy symptoms may improve long-term prognosis of the patients. Thus, we aimed to investigate the prevalence of the symptoms associated with narcolepsy and its social and psychological association in a sample of Sao Paulo city inhabitants. Methods: We performed a cross-sectional evaluation with 1,008 individuals from the Sao Paulo Epidemiologic Sleep Study (EPISONO). Excessive daytime sleepiness (EDS) was assessed by the Epworth Sleepiness Scale. Volunteers were also asked about the occurrence of cataplectic-like, hypnagogic or hypnopompic hallucinations, and sleep paralysis symptoms. The participants underwent a full-night polysomnography and completed questionnaires about psychological, demographic, and quality of life parameters. Results: We observed a prevalence of 39.2% of EDS, 15.0% of cataplectic-like symptom, 9.2% of hypnagogic or hypnopompic hallucinations, and 14.9% of sleep paralysis in Sao Paulo city inhabitants. A frequency of 6.9% waswai observed when EDS and cataplectic-like symptoms were grouped. The other associations were EDS + hallucinations (4.7%) and EDS + sleep paralysis (7.5%). Symptomatic participants were predominantly women and younger compared with patients without any narcolepsy symptom (n = 451). Narcolepsy symptomatology was also associated with a poor quality of life and symptoms of depression, anxiety, and fatigue. Conclusions: Narcolepsy-related symptoms are associated with poor quality of life and worse psychological parameters. (AU)

FAPESP's process: 14/10255-9 - Inflammatory activation induced by sleep deprivation: possible link between sleep and impairment of lipid metabolism
Grantee:Paula Cristina Alves Araújo
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/15259-2 - Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO
Grantee:Camila Hirotsu
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/14420-1 - The effects of sleep restriction in an animal model of ischemic brain injury
Grantee:Lenise Jihe Kim
Support Opportunities: Scholarships in Brazil - Master