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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise

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Beck, Wladimir Rafael [1] ; Botezelli, Jose Diego [2] ; Pauli, Jose Rodrigo [2] ; Ropelle, Eduardo Rochete [2] ; Gobatto, Claudio Alexandre [1]
Total Authors: 5
[1] Univ Estadual Campinas, Lab Appl Sport Physiol, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Lab Mol Biol Exercise, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 5, DEC 16 2015.
Web of Science Citations: 5

It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation. (AU)

FAPESP's process: 11/13226-1 - Ergogenic response of melatonin during the nadir and acrophase of spontaneous activity: consequences on IKK/Nf-kB via
Grantee:Wladimir Rafael Beck
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/08535-5 - Standardization and validity of aerobic and anaerobic tests in field and laboratory, using free, tethered and half-tethered running, in endurance and sprint runners
Grantee:Claudio Alexandre Gobatto
Support type: Regular Research Grants
FAPESP's process: 12/20501-1 - Molecular responses of continuous and intermitent swimming and of exogenous melatonin in rats: cell signalizers of the intermediary metabolism and from the inflammatory and oxidative stress pathways
Grantee:Claudio Alexandre Gobatto
Support type: Regular Research Grants