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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Randomized in vivo evaluation of photodynamic antimicrobial chemotherapy on deciduous carious dentin

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Steiner-Oliveira, Carolina [1] ; Longo, Priscila Larcher [2] ; Correa Aranha, Ana Cecilia [3] ; Ramalho, Karen Mueller [3] ; Alves Mayer, Marcia Pinto [2] ; Eduardo, Carlos de Paula [3]
Total Authors: 6
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Pediat Dent, BR-13414903 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Dent, Special Lab Lasers Dent, Restorat Dept, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biomedical Optics; v. 20, n. 10 OCT 2015.
Web of Science Citations: 13

The aim of this randomized in vivo study was to compare antimicrobial chemotherapies in primary carious dentin. Thirty-two participants ages 5 to 7 years underwent partial caries removal from deep carious dentin lesions in primary molars and were subsequently divided into three groups: control {[}chlorhexidine and resin-modified glass ionomer cement (RMGIC)], LEDTB {[}photodynamic antimicrobial chemotherapy (PACT) with light-emitting diode associated with toluidine blue solution and RMGIC], and LMB {[}PACT with laser associated with methylene blue solution and RMGIC]. The participants were submitted to initial clinical and radiographic examinations. Demographic features and biofilm, gingival, and DMFT/DMFS indexes were evaluated, in addition to clinical and radiographic followups at 6 and 12 months after treatments. Carious dentin was collected before and after each treatment, and the number of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus casei, Fusobacterium nucleatum, Atopoblum rimae, and total bacteria was established by quantitative polymerase chain reaction. No signs of pain or restoration failure were observed. All therapies were effective in reducing the number of microorganisms, except for S. sobrinus. No statistical differences were observed among the protocols used. All therapies may be considered as effective modern approaches to minimal intervention for the management of deep primary caries treatment. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 11/08392-0 - In vivo randomized antimicrobial effect of the photodynamic therapy on deciduous carious dentin: microbiological, clinical and radiographic analysis
Grantee:Carlos de Paula Eduardo
Support Opportunities: Regular Research Grants
FAPESP's process: 10/07212-5 - In vivo randomized antimicrobial effect of the photodynamic therapy on deciduos carious dentin. Microbiological, clinical and radiographic analysis.
Grantee:Carolina Steiner Oliveira Alarcon
Support Opportunities: Scholarships in Brazil - Post-Doctoral