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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Directed Functionalization of Cyano-Substituted Furans and Thiophenes with TMPMgCl center dot LiCl

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dos Santos, Fernanda M. [1] ; Batista, Joao H. C. [1] ; Vessecchi, Ricardo [2] ; Clososki, Giuliano C. [2, 1]
Total Authors: 4
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucl Pesquisa Prod Nat & Sintet, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Synlett; v. 26, n. 20, p. 2795-2800, DEC 2015.
Web of Science Citations: 3

A number of novel difunctionalized furans and thiophenes has been prepared by the reaction of the cyano-substituted substrates with TMPMgClLiCl followed by the reaction with electrophiles. The crucial metalation step takes place under mild conditions allowing the isolation of desired derivatives in reasonable to good yields. (AU)

FAPESP's process: 13/04766-8 - Applycation of new organometallic reagents in the functionalization of substances of synthetic interest
Grantee:Giuliano Cesar Clososki
Support Opportunities: Regular Research Grants
FAPESP's process: 12/13740-0 - Application of New Organometallic Bases in the functionalization of nitriles of pharmaceutical interest
Grantee:Fernanda Moraes dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/23604-1 - Computational chemistry: a tool to studies of mass spectrometry, reactivity and fragmentation/reaction mechanisms of organic compounds
Grantee:Ricardo Vessecchi Lourenço
Support Opportunities: Regular Research Grants