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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors

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Author(s):
Gianlorenco, A. C. L. [1] ; Canto-de-Souza, A. [2] ; Mattioli, R. [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Carlos, Physiotherapy Dept, Ctr Biol Sci & Hlth, Lab Neurosci, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Psychobiol Grp, Dept Psychol, CECH, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Neuroscience Letters; v. 557, n. B, p. 159-164, DEC 17 2015.
Web of Science Citations: 11
Abstract

Studies have demonstrated the relationship between the histaminergic system and the cerebellum, and we intend to investigate the role of the cerebellar histaminergic system on memory consolidation. This study investigated the effect of intra-cerebellar microinjection of histamine on memory retention of inhibitory avoidance in mice, and the role of H1 and H2 receptors in it. The cerebellar vermis of male mice were implanted with guide cannulae, and after three days of recovery, the inhibitory avoidance test was performed. Immediately after a training session, animals received a microinjection of histaminergic drugs: in the experiment 1, saline (SAL) or histamine (HA 0.54, 1.36, 2.72 or 4.07 nmol); experiment 2, SAL or 1.36 nmol HA 5 min after a pretreatment with 0.16 nmol chlorpheniramine (CPA) or SAL; and experiment 3, SAL or 1.36 nmol HA 5 min after a pretreatment with 2.85 nmol ranitidine (RA) or SAL. Twenty-four hours later, a retention test was performed. The data were analyzed using one-way analysis of variance (ANOVA) and Duncan's tests. In experiment 1, animals microinjected with 1.36 nmol HA showed a higher latency to cross to the dark compartment compared to controls and to 2.72 and 4.07 nmol HA groups. In experiment 2, the combined infusions revealed difference between control (SAL+SAL) and SAL+HA and CPA+HA; while in the experiment 3 the analysis indicated differences in retention latency between mice injected with SAL+SAL and SAL+HA. The groups that received the H2 antagonist RA did not show difference compared to control. These results indicate that 1.36 nmol HA enhances memory consolidation of inhibitory avoidance learning in mice and that the pretreatment with H2 antagonist RA was able to prevent this effect. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/15836-1 - Influence of cerebellar histaminergic neural system on emotional memory in mice
Grantee:Anna Carolyna Lepesteur Gianlorenço
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/17496-3 - Influence of the cerebellar histaminergic system on emotional memory in mice
Grantee:Rosana Mattioli
Support type: Regular Research Grants