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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction of chitosan beads with a copper-naproxen metallodrug

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Author(s):
Martins, Douglas de J. [1] ; Hanif-Ur-Rehman [1] ; Alves Rico, Samara R. [1] ; Costa, Iguatina de M. [1] ; Pio Santos, Andrea C. [1] ; Szszudlowski, Rachel G. [1] ; Silva, Denise de Oliveira [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: RSC ADVANCES; v. 5, n. 109, p. 90184-90192, 2015.
Web of Science Citations: 3
Abstract

This manuscript reports a novel hybrid system containing a copper-drug entrapped into the chitosan biopolymer. Chitosan beads (CTb) were prepared and investigated for interaction with a copper metallodrug (CuNpx) of the naproxen (HNpx) non-steroidal anti-inflammatory drug. The loading capacity of CTb for CuNpx suggests a sponge-like behavior for copper-drug entrapping at a CuNpx concentration range from 10(-4) to 10(-2) mol L-1. A novel CTb/CuNpx hybrid material formed by the copper-drug loaded into chitosan beads was prepared and characterized by elemental analysis, scanning electron microscopy, electronic absorption spectroscopy, FTIR spectroscopy, X-ray diffractometry and thermal analysis. The CTb/CuNpx hybrid material was coated with Acrycoat S100, and its behavior in gastric/intestinal pH simulated solutions was investigated to verify potential releasing properties. The coated beads showed a capacity to release naproxen in a sustained release manner for at least 24 h. (AU)

FAPESP's process: 11/06592-1 - Anti-inflammatory and antitumor metallotherapeutic drugs: reactivity, properties and interactions with biocompatible hosts
Grantee:Denise de Oliveira Silva
Support type: Regular Research Grants
FAPESP's process: 05/60596-8 - Complex species with potential for application in bio-organics, catalysis, pharmacology and environmental chemistry: conception, preparation, characterization and reactivity
Grantee:Ana Maria da Costa Ferreira
Support type: Research Projects - Thematic Grants