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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

IFN-gamma Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases

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da Silva, Henrique Borges [1, 2] ; Fonseca, Raissa [1] ; Alvarez, Jose M. [1] ; D'Imperio Lima, Maria Regina [1]
Total Authors: 4
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55414 - USA
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 2

Although it has been established that effector memory CD4(+) T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-gamma priming as a mechanism affecting both innate immune cells and effector memory CD4(+) T cells. Suboptimal concentrations of IFN-gamma are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4(+) T cells. Thus, IFN-gamma priming can thus be considered an important bridge between innate and adaptive immunity. (AU)

FAPESP's process: 14/00810-5 - IFN-gamma-induced priming during chronic experimental malaria: study of the molecular and effector mechanisms involved
Grantee:Henrique Borges da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07140-2 - Role of inflammasomas in the pathogenesis of tuberculosis caused by hypervirulent clinical isolates of mycobacteria
Grantee:Maria Regina D'Império Lima
Support Opportunities: Regular Research Grants