IFN-gamma Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases

Although it has been established that effector memory CD4(+) T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-gamma priming as a mechanism affecting both innate immune cells and effector memory CD4(+) T cells. Suboptimal concentrations of IFN-gamma are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4(+) T cells. Thus, IFN-gamma priming can thus be considered an important bridge between innate and adaptive immunity. (AU)