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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute Biphasic Effects of Ayahuasca

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Schenberg, Eduardo Ekman [1] ; Morel Alexandre, Joao Felipe [2] ; Filev, Renato [1] ; Cravo, Andre Mascioli [2] ; Sato, Joao Ricardo [2] ; Muthukumaraswamy, Suresh D. [3, 4] ; Yonamine, Mauricio [5] ; Waguespack, Marian [6] ; Lomnicka, Izabela [6] ; Barker, Steven A. [6] ; da Silveira, Dartiu Xavier [1]
Total Authors: 11
[1] Univ Fed Sao Paulo, Dept Psiquiatria, Sao Paulo - Brazil
[2] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre - Brazil
[3] Univ Auckland, Sch Pharm, Auckland 1 - New Zealand
[4] Univ Auckland, Sch Psychol, Auckland 1 - New Zealand
[5] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
[6] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 - USA
Total Affiliations: 6
Document type: Journal article
Source: PLoS One; v. 10, n. 9 SEP 30 2015.
Web of Science Citations: 20

Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca's compounds and their metabolites in the systemic circulation we found ayahuasca to induce a biphasic effect in the brain. This effect was composed of reduced power in the alpha band (8-13 Hz) after 50 minutes from ingestion of the brew and increased slow- and fast-gamma power (30-50 and 50-100 Hz, respectively) between 75 and 125 minutes. Alpha power reductions were mostly located at left parieto-occipital cortex, slow-gamma power increase was observed at left centro-parieto-occipital, left fronto-temporal and right frontal cortices while fast-gamma increases were significant at left centro-parieto-occipital, left fronto-temporal, right frontal and right parieto-occipital cortices. These effects were significantly associated with circulating levels of ayahuasca's chemical compounds, mostly N, N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine and some of their metabolites. An interpretation based on a cognitive and emotional framework relevant to the ritual use of ayahuasca, as well as it's potential therapeutic effects is offered. (AU)

FAPESP's process: 11/11341-8 - Evaluation of the electrophysiological alterations on healthy subjects EEG during the effect of ayahuasca
Grantee:Eduardo Ekman Schenberg
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/07540-3 - Statistical analysis of electrophysiological signals from the human brain during the effects of ayahuasca
Grantee:Eduardo Ekman Schenberg
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 12/07699-7 - Neurophysiological assessment of ayahuasca's effects in humans
Grantee:Dartiu Xavier da Silveira
Support Opportunities: Regular Research Grants