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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinicopathological and immunohistochemical evaluation of oesophageal leiomyosarcoma in a dog

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Ciccone Alves, Renata Cintra [1] ; Batista, Tatiana Linardi [1] ; Laufer-Amorim, Renee [2] ; Elias, Fabiana [3] ; Calazans, Sabryna Gouveia [4] ; Fonseca-Alves, Carlos Eduardo [5]
Total Authors: 6
[1] Fac Jaguariuna FAJ, Programa Posgrad Oncol Vet, Jaguariuna, SP - Brazil
[2] Univ Estadual Paulista UNESP, FMVZ, BR-18609020 Botucatu, SP - Brazil
[3] UFFS, Realeza, PR - Brazil
[4] Univ Fed Franca UNIFRAN, Dept Vet Med, Franca, SP - Brazil
[5] Univ Estadual Paulista UNESP, Programa Posgrad Med Vet, BR-18609020 Botucatu, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Ciência Rural; v. 45, n. 9, p. 1644-1647, SEP 2015.
Web of Science Citations: 1

<p>Oesophageal leiomyosarcoma is a malignant neoplasm of smooth muscle fibres that is infrequently reported in the literature. Because of the importance of definitive diagnosis and the low incidence of this tumour in dogs, it was reported a case of oesophageal leiomyosarcoma in a dog. A 13-year-old intact male Rottweiler presented regurgitation, hyporexia, and chronic weight loss. After an imaging examination, tumour in the thoracic oesophagus was suspected and a biopsy was sugested for definitive diagnosis. However, the owner did not permit the procedure. Six months after the clinical diagnosis, the patient was brought for evaluation of anorexia, apathy, and severe dyspnoea. Because of the patient's clinical signs and lack of response to emergency treatment, he was euthanized. Upon necropsy, it was identified the neoplastic formation, previously identified in the radiographic examination in the thoracic oesophagus, near the diaphragm. Histopathology revealed a proliferation of mesenchymal cells, and the diagnosis of leiomyosarcoma was confirmed by immunohistochemical examination. Despite the low incidence of oesophageal leiomyosarcoma, it should be included as a differential diagnosis for animals with chronic regurgitation.</p> (AU)

FAPESP's process: 12/18426-1 - Epigenetic evaluation of NKX3.1 and CDH1 and immunohistochemistry expression of C-MYC, NKX3.1 and E-cadherin on tissue microarray (TMA) of pre-neoplastic and neoplastic prostate of dogs
Grantee:Carlos Eduardo Fonseca Alves
Support Opportunities: Scholarships in Brazil - Doctorate