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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Stem Cell Marker Bmi-1 Is Sensitive in Identifying Early Lesions of Carcinoma ex Pleomorphic Adenoma

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Sedassari, Bruno Tavares [1] ; Setubal Destro Rodrigues, Maria Fernanda [1] ; Mariano, Fernanda Viviane [2] ; Altemani, Albina [2] ; Nunes, Fabio Daumas [1] ; Sousa, Suzana [1]
Total Authors: 6
[1] Univ Sao Paulo, Sch Dent, Dept Oral & Maxillofacial Pathol, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Estadual Campinas, Sch Med, Dept Anat Pathol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MEDICINE; v. 94, n. 27 JUL 2015.
Web of Science Citations: 1

In the present study, we evaluated and described the sensitivity of the stem cell marker B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) in identifying early lesions of carcinoma ex pleomorphic adenoma (CXPA). While invasive CXPAs are tumors with a prominent and easily recognizable malignant component, the identification of early carcinomatous changes in PA remains a diagnostic challenge due to the lack of objective morphological criteria. The immunohistochemical expression of Bmi-1 was assessed in both adenomatous and carcinomatous components of 9 CXPA cases at an early phase of histological progression (6 intracapsular and 3 minimally invasive) grouped according to the cellular differentiation as luminal (7 cases) or myoepithelial (2 cases). A selective nuclear expression of Bmi-1 was found exclusively in the malignant component of 8 cases (6 luminal type and 2 myoepithelial type), including intraductal carcinoma areas, except for 1 case in which scarce cells of the remnant PA were positive. Thus, Bmi-1 is expressed from the earliest morphologically detectable stages of PA malignant transformation. When faced with atypical features in PA, evaluation of Bmi-1 expression can provide more objective criteria for identification and diagnosis of early lesions of CXPA. This is applied to carcinomas with luminal or myoepithelial differentiation. (AU)

FAPESP's process: 12/00786-1 - Functional analysis of cell signaling involvement in cancer stem cells obtained from oral squamous cell carcinoma cell lines
Grantee:Fabio Daumas Nunes
Support Opportunities: Regular Research Grants