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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytokines and Bone-Related Factors in Systemically Healthy Patients With Chronic Periodontitis and Patients With Type 2 Diabetes and Chronic Periodontitis

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Ribeiro, Fernanda Vieira [1] ; de Mendonca, Adriana Cutrim [1] ; Santos, Vanessa Renata [1] ; Bastos, Marta Ferreira [1] ; Figueiredo, Luciene Cristina [1] ; Duarte, Poliana Mendes [1]
Total Authors: 6
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Periodontology; v. 82, n. 8, p. 1187-1196, AUG 2011.
Web of Science Citations: 53

Background: This study compares the levels of cytokines and bone-related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better-controlled, and poorly controlled patients with type 2 diabetes and CP. Methods: Thirty-seven patients with type 2 diabetes and CP and 20 systemically healthy patients with CP were enrolled in this study. The patients with diabetes mellitus were categorized as better-controlled (n = 17; HbA(1c) levels <= 8%) or poorly controlled (n = 20; glycated hemoglobin values >8%). Levels of tumor necrosis factor-alpha, interleukin (IL)-4, interferon (IFN)-gamma, IL-23, IL-17, soluble receptor activator of nuclear factor-kappa B ligand (sRANKL), and osteoprotegerin (OPG) in GCF of diseased sites were analyzed by enzyme-linked immunosorbent assay. Results: Type 2 diabetes mellitus, as a whole, upregulates the levels of OPG, sRANKL, IFN-gamma, IL-17, and IL-23 and downregulates the production of IL-4 in sites with CP (P<0.05). Better-controlled individuals exhibited the highest levels of IFN-gamma, whereas poorly controlled patients presented the highest levels of IL-17 (P <0.05). There were no differences in the levels of tumor necrosis factor-a, OPG, and IL-23 among systemically healthy, better-controlled, and poorly controlled patients with diabetes (P>0.05). Conclusions: Increased levels of proinflammatory cytokines and RANKL were observed in the GCF of patients with type 2 diabetes with CP, compared to patients without diabetes. In addition, poor or good glycemic status seems to modulate osteo-immunoinflammatory mediators in a different manner. J Periodontol 2011;82:1187-1196. (AU)

FAPESP's process: 08/09687-0 - Periodontal treatment in controlled and uncontrolled Diabetic subjects: clinical, glycemic and cytokine and bone resorption related factors evaluations
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants
FAPESP's process: 08/04280-0 - Gene expression in sites with chronic periodontitis in diabetic individuals
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants