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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrospun nanofibrous scaffolds of segmented polyurethanes based on PEG, PLLA and PTMC blocks: Physico-chemical properties and morphology

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Trinca, Rafael Bergamo [1] ; Abraham, Gustavo A. [2] ; Felisberti, Maria Isabel [1]
Total Authors: 3
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil
[2] UNMdP CONICET, Res Inst Mat Sci & Technol INTEMA, Mar Del Plata, Buenos Aires - Argentina
Total Affiliations: 2
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 56, p. 511-517, NOV 1 2015.
Web of Science Citations: 21

Biocompatible polymeric scaffolds are crucial for successful tissue engineering. Biomedical segmented polyurethanes (SPUs) are an important and versatile class of polymers characterized by a broad spectrum of compositions, molecular architectures, properties and applications. Although SPUs are versatile materials that can be designed by different routes to cover a wide range of properties, they have been infrequently used for the preparation of electrospun nanofibrous scaffolds. This study reports the preparation of new electrospun polyurethane scaffolds. The segmented polyurethanes were synthesized using low molar masses macrodyols (poly(ethylene glycol), poly(L-lactide) and poly(trimethylene carbonate)) and 1,6-hexane diisocyanate and 1,4-butanodiol as isocyanate and chain extensor, respectively. Different electrospinning parameters such as solution properties and processing conditions were evaluated to achieve smooth, uniform bead-free fibers. Electrospun micro/nanofibrous structures with mean fiber diameters ranging from 600 nm to 770 nm were obtained by varying the processing conditions. They were characterized in terms of thermal and dynamical mechanical properties, swelling degree and morphology. The elastomeric polyurethane scaffolds exhibit interesting properties that could be appropriate as biomimetic matrices for soft tissue engineering applications. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 10/17804-7 - Polymeric composites
Grantee:Maria Isabel Felisberti
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/02098-0 - Multicomponent polymeric materials
Grantee:Maria Isabel Felisberti
Support Opportunities: Regular Research Grants
FAPESP's process: 11/09479-1 - Multicomponent segmented polyurethanes
Grantee:Rafael Bergamo Trinca
Support Opportunities: Scholarships in Brazil - Doctorate