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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Receptor Activator of Nuclear Factor-Kappa B Ligand/Osteoprotegerin Ratio in Sites of Chronic Periodontitis of Subjects With Poorly and Well-Controlled Type 2 Diabetes

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Santos, Vanessa Renata ; Lima, Jadson Almeida ; Dias Goncalves, Tiago Eduardo ; Bastos, Marta Ferreira ; Figueiredo, Luciene Cristina ; Shibli, Jamil Awad ; Duarte, Poliana Mendes [1]
Total Authors: 7
[1] Univ Guarulhos, Dent Res Div, Ctr Guarulhos, Dept Periodontol, BR-07023070 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Periodontology; v. 81, n. 10, p. 1455-1465, OCT 2010.
Web of Science Citations: 35

Background: The aim of this study is to evaluate the levels of osteoclastogenesis-related factors (soluble receptor activator of nuclear factor-kappa B ligand {[}sRANKL] and osteoprotegerin {[}OPG]) in gingival crevicular fluid (GCF) from subjects with poorly and well-controlled type 2 diabetes and chronic periodontitis before and after periodontal therapy. Methods: Eighteen subjects with well-controlled diabetes (glycated hemoglobin {[}HbA1c] levels <= 8%) and 20 subjects with poorly controlled diabetes (HbA1c levels >8%) were enrolled in this study. All subjects were submitted to non-surgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed at baseline and 3 and 6 months post-therapy. Total amounts and concentrations of sRANKL and OPG in GCF were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Total amounts and concentrations of sRANKL and RANKL/OPG ratios were higher in poorly controlled subjects than in well-controlled subjects at baseline and 3 and 6 months post-therapy (P<0.05). In addition, RANKL/OPG ratios decreased in well-controlled subjects (P<0.05) but not in poorly controlled subjects (P>0.05) at 3 months post-therapy. Almost all clinical parameters improved significantly for both groups post-treatment (P<0.05). Conclusion: RANKL/OPG ratios in untreated and treated periodontitis sites may be negatively influenced by poor glycemic control in subjects with type 2 diabetes. J Periodontol 2010;81:1455-1465. (AU)

FAPESP's process: 08/09687-0 - Periodontal treatment in controlled and uncontrolled Diabetic subjects: clinical, glycemic and cytokine and bone resorption related factors evaluations
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants