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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study

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Mendonca, Adriana Cutrim [1] ; Santos, Vanessa Renata [1] ; Ribeiro, Fernanda Vieira [1] ; Lima, Jadson Almeida [1] ; Miranda, Tamires Szeremeske [1] ; Feres, Magda [1] ; Duarte, Poliana Mendes [1]
Total Authors: 7
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Clinical Periodontology; v. 39, n. 4, p. 368-376, APR 2012.
Web of Science Citations: 9

Aim: This study evaluated the effects of surgical (SD) and non-surgical (NSD) debridements, associated with systemic antimicrobials, on clinical and immunological outcomes of residual pockets {[} RP; probing depth (PD) >= 5 mm with bleeding on probing] in type 2 diabetics. Material and Methods: A split-mouth, randomized controlled trial was conducted in 21 subjects presenting at least two RP per contralateral quadrant. Subjects received metronidazole plus amoxicillin for 10 days and, contralateral quadrants were assigned to receive SD or NSD. Clinical parameters and local levels of interferon- c, interleukin (IL)-17, IL-23 and IL-4 were assessed at baseline, 3 and 6 months post-therapies. Results: Overall, the mean number, PD and clinical attachment level (CAL) of RP improved significantly after therapies (p < 0.05), without differences between groups at any time-point (p > 0.05). At quadrant level, only SD produced significant reductions in the mean CAL. Also, SD promoted higher reduction in PD from baseline to 6 months than NSD (p < 0.05). Levels of all cytokines were increased after SD compared with NSD (p < 0.05). Conclusion: SD and NSD associated with systemic antimicrobials did not differ in terms of clinical benefits for RP in diabetics up to 6 months post-therapies. RP treated by SD presented increased levels of cytokines. (AU)

FAPESP's process: 08/09687-0 - Periodontal treatment in controlled and uncontrolled Diabetic subjects: clinical, glycemic and cytokine and bone resorption related factors evaluations
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants
FAPESP's process: 08/04280-0 - Gene expression in sites with chronic periodontitis in diabetic individuals
Grantee:Poliana Mendes Duarte
Support Opportunities: Regular Research Grants