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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

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Cezar, Marcelo D. M. [1] ; Damatto, Ricardo L. [1] ; Pagan, Luana U. [1] ; Lima, Aline R. R. [1] ; Martinez, Paula F. [2] ; Bonomo, Camila [1] ; Rosa, Camila M. [1] ; Campos, Dijon H. S. [1] ; Cicogna, Antonio C. [1] ; Gomes, Mariana J. [1] ; Oliveira-, Jr., Silvio A. [2] ; Blotta, Daniella A. [1] ; Okoshi, Marina P. [1] ; Okoshi, Katashi [1]
Total Authors: 14
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil
[2] Univ Fed Mato Grosso do Sul, Campo Grande - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 36, n. 4, p. 1453-1466, 2015.
Web of Science Citations: 20

Background: We evaluated the role of the aldosterone blocker spironolactone in attenuating long-term pressure overload-induced cardiac remodeling and heart failure (HF) in spontaneously hypertensive rats (SHR). Methods and Results: Thirteen month-old male SHR were assigned to control (SHR-C, n=20) or spironolactone (SHR-SPR, 20 mg/kg/day, n=24) groups for six months. Normotensive Wistar-Kyoto rats (WKY, n=15) were used as controls. Systolic blood pressure was higher in SHR groups and unchanged by spironolactone. Right ventricular hypertrophy, which characterizes HF in SHR, was less frequent in SHR-SPR than SHR-C. Echocardiographic parameters did not differ between SHR groups. Myocardial function was improved in SHR-SPR compared to SHR-C {[}developed tension: WKY 4.85 +/- 0.68; SHR-C 5.22 +/- 1.64; SHR-SPR 6.80 +/- 1.49 g/mm(2); -dT/dt: WKY 18.0 (16.0-19.0); SHR-C 20.8 (18.4-25.1); SHR-SPR 28.9 (24.2-34.6) g/mm(2)/s]. Cardiomyocyte cross-sectional area and total collagen concentration (WKY 1.06 +/- 0.34; SHR-C 1.85 +/- 0.63; SHR-SPR 1.28 +/- 0.39 mu g/mg wet tissue) were greater in SHR-C than WKY and SHR-SPR. Type 3 collagen expression was lower in SHR-C than WKY and unchanged by spironolactone. Soluble collagen, type I collagen, and lysyl oxidase did not differ between groups. Conclusion: Early spironolactone treatment decreases heart failure development frequency by improving myocardial systolic and diastolic function and attenuating hypertrophy and fibrosis in spontaneously hypertensive rats. Copyright (C) 2015 S. Karger AG, Basel (AU)

FAPESP's process: 09/54102-3 - Acquisition of an ultracentrifuge and an echocardiograph to equip a Centralized Multi-User Laboratory
Grantee:Marina Politi Okoshi
Support Opportunities: Multi-user Equipment Program