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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

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Florencio-Silva, Rinaldo [1] ; da Silva Sasso, Gisela Rodrigues [1] ; Sasso-Cerri, Estela [2] ; Simoes, Manuel Jesus [1] ; Cerri, Paulo Sergio [2]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Lab Histol & Struct Biol, BR-04023900 Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, Sch Dent, Dept Morphol, Lab Histol & Embryol, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 194

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling. (AU)

FAPESP's process: 12/19428-8 - Evaluation of autophagy and cell death in osteocytes of alveolar bone in ovariectomized female rats treated with estrogen
Grantee:Paulo Sergio Cerri
Support type: Regular Research Grants
FAPESP's process: 12/22666-8 - Cellular and molecular mechanisms during the early development of rat alveolar bone
Grantee:Paulo Sergio Cerri
Support type: Regular Research Grants
FAPESP's process: 10/10391-9 - Effect of cimetidine in the evolution of periodontitis in rat molars: morphometrical, immunohistochemical and ultrastructural evaluation
Grantee:Paulo Sergio Cerri
Support type: Regular Research Grants