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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial

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Carvalho, Veronica F. [1] ; Andrade, Priscila V. C. [1] ; Rodrigues, Michelle F. [1] ; Hirata, Mario H. [2] ; Hirata, Rosario D. C. [2] ; Pannuti, Claudio M. [1] ; De Micheli, Giorgio [1] ; Conde, Marina C. [1]
Total Authors: 8
[1] Univ Sao Paulo, Sch Dent, Dept Periodontol, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Clinical Periodontology; v. 42, n. 5, p. 440-447, MAY 2015.
Web of Science Citations: 21

AimA randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (PDT) in the treatment of residual pockets of chronic periodontitis patients. Material and MethodsThirty-four patients with at least four residual periodontal pockets undergoing maintenance care were included and randomly assigned to test group (PDT, n=18) or control group (sham procedure, n=16). The intervention was performed at baseline, 3, 6 and 12months. Clinical parameters such as pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque index (PI) were measured before intervention and after 3, 6 and 12months. Subgingival samples were obtained at baseline, and after 7days, 3, 6 and 12months to quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia by real-time polimerase chain reaction (PCR). ResultsAll clinical variables showed significant improvement during the study, but there was no significant difference between test and control groups. The microbiological analyses showed no differences between groups at any time during the study. ConclusionWithin the limits of this clinical trial and considering the laser and photosensitizer protocol used, PDT failed to demonstrate additional clinical and bacteriological benefits in residual pockets treatment. (AU)

FAPESP's process: 09/53934-5 - Photodynamic therapy as a co-adjutant to non-surgical treatment of chronic periodontitis: a randomized, controlled clinical trial
Grantee:Giorgio de Micheli
Support Opportunities: Regular Research Grants